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Donald R Kirsch Selected Research

pyrazolone

8/2015Tertiary Amine Pyrazolones and Their Salts as Inhibitors of Mutant Superoxide Dismutase 1-Dependent Protein Aggregation for the Treatment of Amyotrophic Lateral Sclerosis.
9/2014Proteasome activation is a mechanism for pyrazolone small molecules displaying therapeutic potential in amyotrophic lateral sclerosis.
1/2012ADME-guided design and synthesis of aryloxanyl pyrazolone derivatives to block mutant superoxide dismutase 1 (SOD1) cytotoxicity and protein aggregation: potential application for the treatment of amyotrophic lateral sclerosis.

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Donald R Kirsch Research Topics

Disease

5Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
08/2015 - 01/2012
1Cross Infection (Nosocomial Infection)
05/2020
1Neurodegenerative Diseases (Neurodegenerative Disease)
01/2012

Drug/Important Bio-Agent (IBA)

3Proteins (Proteins, Gene)FDA Link
08/2015 - 01/2012
3Superoxide Dismutase-1IBA
08/2015 - 01/2012
3pyrazoloneIBA
08/2015 - 01/2012
1Anti-Bacterial Agents (Antibiotics)IBA
05/2020
1Superoxide DismutaseIBA
08/2015
1SaltsIBA
08/2015
1AminesIBA
08/2015
1PyrazolonesIBA
08/2015
1Proteasome Endopeptidase Complex (Proteasome)IBA
09/2014
1CyclohexaneIBA
05/2012